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| 카탈로그 번호 | JN878016 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Clostridium perfringens | ||||
| 응용 분야 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo | ||||
| 숙주 종 | Human | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG1 | ||||
| 클론 ID | 3a4D10 | ||||
| 발현 시스템 | Mammalian cells | ||||
| 타겟 | Phospholipase C, PLC, 3.1.4.3, Alpha-toxin, Hemolysin, Lecithinase, Phosphatidylcholine cholinephosphohydrolase, plc, cpa | ||||
| 내독소 수준 | < 10 EU/mg | ||||
| 순도 | >95% purity as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | Q9RF12 | ||||
| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 배경 | Phospholipase C (plcAlpha-toxin) is a ~45 kDa protein. Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Constitutes an essential virulence factor in gas gangrene. Binds to eukaryotic membranes where it hydrolyzes both phosphatidylcholine and sphingomyelin, causing cell rupture. The diacylglycerol produced can activate both the arachidonic acid pathway, leading to modulation of the inflammatory response cascade and thrombosis, and protein kinase C, leading to activation of eukaryotic phospholipases and further membrane damage. | ||||
| 참고 문헌 | 1. Singh V, et al. Phospholipase C: underrated players in microbial infections. Front Cell Infect Microbiol. 2023 Apr 17;13:1089374. [JN878016] | ||||
| 참고사항 | For research use only. Not suitable for clinical or therapeutic use. |
SDS-PAGE for Research Grade Anti-Clostridium perfringens plcAlpha-toxin Antibody (3a4D10)
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
