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| 카탈로그 번호 | HX193016 |
|---|---|
| 설명 |
Anti-Human BACE1 Antibody (Genentech anti-BACE1) (HX193016) is a research-grade recombinant antibody targeting BACE1. Produced in mammalian cells with native-like glycosylation.
Highlights
|
| 종 반응성 | Human |
| 응용 분야 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 숙주 종 | Human |
| 이소타입 | IgG |
| 클론 ID | Genentech anti-BACE1 |
| 발현 시스템 | Mammalian cells |
| 타겟 | BACE1, Memapsin-2, KIAA1149, Asp 2, Beta-site amyloid precursor protein cleaving enzyme 1, BACE, Beta-site APP cleaving enzyme 1, Beta-secretase 1, Aspartyl protease 2, ASP2, Membrane-associated aspartic protease 2, BACE1 |
| 내독소 수준 | < 10 EU/mg |
| 순도 | >95% purity as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | P56817 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 배경 | Beta-secretase 1 (BACE1) is a ~55 kDa protein. Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. Cleaves CHL1. 1. Hussain, I. et al. (1999) Molecular and cellular neurosciences 14, 419-27. PMID: 10656250 2. Lin, X. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 1456-60. PMID: 10677483 3. Okada, H. et al. (2010) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 24, 2783-94. PMID: 20354142 |
| 참고사항 | For research use only. Not suitable for clinical or therapeutic use. |
SDS-PAGE for Research Grade Anti-Human BACE1 Antibody (Genentech anti-BACE1)
+86-027-65523339
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