Anti-BACE1 Polyclonal Antibody (HX193014)

Name: Anti-BACE1 Polyclonal Antibody
Brand: abinScience
SKU: HX193014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HX193014

Description

Anti-BACE1 Polyclonal Antibody (HX193014) is a rabbit polyclonal antibody detecting BACE1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Cavia porcellus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human BACE1 (Glu46-Thr457).

Target

BACE1, Memapsin-2, KIAA1149, Asp 2, Beta-site amyloid precursor protein cleaving enzyme 1, BACE, Beta-site APP cleaving enzyme 1, Beta-secretase 1, Aspartyl protease 2, ASP2, Membrane-associated aspartic protease 2

Purification

Purified by antigen affinity column.

Accession

P56817

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Beta-secretase 1 (BACE1) is a ~55 kDa protein. Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. Cleaves CHL1.

1. Hussain, I. et al. (1999) Molecular and cellular neurosciences 14, 419-27. PMID: 10656250

2. Lin, X. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 1456-60. PMID: 10677483

3. Okada, H. et al. (2010) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 24, 2783-94. PMID: 20354142

Note

For research use only.

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