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| 카탈로그 번호 | HP481016 |
|---|---|
| 종 반응성 | Human |
| 응용 분야 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 숙주 종 | Human |
| 클론성 | Monoclonal |
| 이소타입 | IgG1 |
| 클론 ID | MVT-5873 |
| 생물학적 활성 | Sialyl Lewis A mediates adhesion of human colon, pancreas, and gastric cancer cells to E-selectin-expressing endothelial cells, with complete abolition of this adhesion when Sialyl Lewis A expression is suppressed via antisense FT III cDNA transfection [1]. Sialyl Lewis A mediates adhesion of human urinary bladder cancer Hu 1703He cells to E-selectin-expressing CHO cells [1]. Sialyl Lewis A expression is required for the tumorigenicity of human squamous lung cancer cells in athymic nu/nu nude mice [1]. Sialyl Lewis A mediates nearly exclusive ELAM-1-dependent adhesion of Capan2, 2102Ep, QG90, Colo201, WiDr, and SW1116 human epithelial cancer cell lines to rIL1β-activated HUVECs [2]. Sialyl Lewis A is strongly expressed on the surface of Capan2, 2102Ep, QG90, Colo201, WiDr, and SW1116 human epithelial cancer cell lines, but is not detected on any of the 12 tested human leukemia cell lines [2]. Sialyl Lewis A does not contribute to the adhesion of any of the 12 tested human leukemia cell lines to rIL1β-activated HUVECs [2]. |
| 발현 시스템 | Mammalian cells |
| 타겟 | CA19-9, Sialyl Lewis A, sLe A |
| 내독소 수준 | < 10 EU/mg |
| 순도 | >95% purity as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | HuMab-5B1, MVT-5873 |
| 참고 문헌 | 1. Ugorski M, et al. Sialyl Lewis(a): a tumor-associated carbohydrate antigen involved in adhesion and metastatic potential of cancer cells. Acta Biochim Pol. 2002;49(2):303-311. [HP481016] 2. Takada A, et al. Contribution of carbohydrate antigens sialyl Lewis A and sialyl Lewis X to adhesion of human cancer cells to vascular endothelium. Cancer Res. 1993 Jan 15;53(2):354-61. [HP481016] 3. Ma Z, et al. Expression of the Carbohydrate Lewis Antigen, Sialyl Lewis A, Sialyl Lewis X, Lewis X, and Lewis Y in the Placental Villi of Patients With Unexplained Miscarriages. Front Immunol. 2021;12:679424. Published 2021 May 31. [HP481016] |
| 참고사항 | For research use only. Not suitable for clinical or therapeutic use. |
SDS-PAGE for Research Grade Anti-Human CA19-9/Sialyl Lewis A (sLe A) Antibody (MVT-5873)
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