Anti-Human GFR alpha-like Reference Antibody (NGM120, RUO) (HS720016)

Name: Anti-Human GFR alpha-like Reference Antibody (NGM120, RUO)
Brand: abinScience
SKU: HS720016
Price: 176 USD
Availability: InStock

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개요

카탈로그 번호	HS720016
설명	Anti-Human GFRAL (NGM120) (HS720016) is a research-grade recombinant antibody targeting C6orf144. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
종 반응성	Human
응용 분야	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
숙주 종	Human
클론성	Monoclonal
이소타입	IgG
클론 ID	NGM120
발현 시스템	Mammalian cells
타겟	C6orf144, GDNF family receptor alpha-like, GFRAL
내독소 수준	< 10 EU/mg
순도	>95% purity as determined by SDS-PAGE.
정제	Protein A/G purified from cell culture supernatant.
등록번호	Q6UXV0
형태	Liquid
저장 완충액	0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
대체 이름	NGM120
배경	GDNF family receptor alpha-like (GFRAL) is a ~44 kDa protein. Brainstem-restricted receptor for GDF15 hormone, which triggers an aversive response, characterized by nausea, vomiting, and/or loss of appetite in response to various stresses. The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future. The GDF15-GFRAL aversive response is triggered by stresses, such as anticancer drugs (camptothecin or cisplatin), cancers or drugs such as metformin. Upon interaction with its ligand, GDF15, mediates the GDF15-induced autophosphorylation and activation of the RET tyrosine kinase receptor, leading to activation of MAPK- and AKT- signaling pathways. Ligand-binding activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem. 1. Mullican, SE. et al. (2017) Nature medicine 23, 1150-1157. PMID: 28846097 2. Emmerson, PJ. et al. (2017) Nature medicine 23, 1215-1219. PMID: 28846098 3. Yang, L. et al. (2017) Nature medicine 23, 1158-1166. PMID: 28846099 4. Hsu, JY. et al. (2017) Nature 550, 255-259. PMID: 28953886 5. Benichou, O. et al. (2023) Cell metabolism 35, 274-286.e10. PMID: 36630958 7. Li, J. et al. (2019) eLife 8. PMID: 31535977
참고사항	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 (LALA) Recombinant Isotype Control Antibody (HyHEL-10) (HP688107)

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SDS-PAGE

SDS-PAGE for Research Grade Anti-Human GFRAL (NGM120).
Western blot

Western blot analysis was performed using anti-GFRAL monoclonal antibody at 1μg/ml on various samples.
Lane 1: recombinant human GFRAL (Catalog No: HS720011), 50ng
Lane 2: recombinant human GFRAL (Catalog No: HS720011), 30ng

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Anti-Human GFR alpha-like Reference Antibody (NGM120, RUO).pdf

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Anti-Human GFR alpha-like Reference Antibody (NGM120, RUO) (HS720016)

개요

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참고 문헌

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