Anti-Human IL-11 Reference Antibody (X203, RUO) (HB978016)

Name: Anti-Human IL-11 Reference Antibody (X203, RUO)
Brand: abinScience
SKU: HB978016
Price: 176 USD
Availability: InStock

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개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호	HB978016
설명	Anti-Human IL11 Antibody (X203) (HB978016) is a research-grade recombinant antibody targeting Adipogenesis inhibitory factor. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
종 반응성	Human
응용 분야	ELISA, Functional assay, Research in vivo
숙주 종	Human
클론성	Monoclonal
이소타입	IgG1, kappa
클론 ID	X203
발현 시스템	Mammalian cells
테스트된 응용 분야	WB
타겟	Adipogenesis inhibitory factor, AGIF, IL11, IL-11, Interleukin-11, Oprelvekin
내독소 수준	< 10 EU/mg
순도	>95% purity as determined by SDS-PAGE.
정제	Protein A/G purified from cell culture supernatant.
등록번호	P20809
형태	Liquid
저장 완충액	0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
대체 이름	EnX203, EnX203, EnX-203, X203
배경	Interleukin-11 (IL11) is a ~21 kDa protein. Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation. Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling'. 1. Paul, SR. et al. (1990) Proceedings of the National Academy of Sciences of the United States of America 87, 7512-6. PMID: 2145578 2. Harmegnies, D. et al. (2003) The Biochemical journal 375, 23-32. PMID: 12919066 3. Lamertz, L. et al. (2018) Science signaling 11. PMID: 30279168
참고사항	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 (LALA) Recombinant Isotype Control Antibody (HyHEL-10) (HP688107) Human IgG1 (LALAPG) Recombinant Isotype Control Antibody (HyHEL-10) (HP688307)

이미지

SDS-PAGE

SDS-PAGE for Research Grade Anti-Human IL11 Antibody (X203).
Bioactivity

Detects Human IL11 in indirect ELISAs.
Bioactivity

Detects Recombinant Human IL11 Protein, N-His (Catalog No: HB978012) in indirect ELISAs.
Bioactivity

Detects Recombinant Human IL11 Protein, N-His (Catalog No: HB978022) in indirect ELISAs.
Bioactivity

Detects Recombinant Human IL11 Protein, N-His (Catalog No: HB978032) in indirect ELISAs.
Western blot

Western blot analysis was performed using anti-IL11 monoclonal antibody at 1μg/ml on various samples.
Lane 1: recombinant human IL11 (Catalog No: HB978012), 50ng
Lane 2: recombinant human IL11 (Catalog No: HB978012), 30ng
Western blot

Western blot analysis was performed using anti-/ monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant feline IL-11