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| 카탈로그 번호 | HV045016 |
|---|---|
| 설명 |
Anti-Human IL-1Rrp2/IL-1R6 Reference Antibody (REGN6490, RUO) (HV045016) is a human monoclonal antibody detecting IL-1Rrp2/IL-1R6. Expressed in Mammalian cells.
|
| 종 반응성 | Human |
| 응용 분야 | ELISA, Bioactivity: FCM, Functional assay, Research in vivo |
| 숙주 종 | Human |
| 클론성 | Monoclonal |
| 이소타입 | IgG4, kappa |
| 클론 ID | REGN6490 |
| 발현 시스템 | Mammalian cells |
| 성질 | Recombinant |
| 타겟 | IL1R-rp2, IL1RL2, IL1RRP2, IL-1Rrp2, IL-36 receptor, Interleukin-1 receptor-related protein 2, Interleukin-1 receptor-like 2, IL-36R |
| 내독소 수준 | < 10 EU/mg as determined by LAL method. |
| 순도 | >95% as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | Q9HB29 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | REGN6490 |
| 배경 | Interleukin-1 receptor-like 2 (IL1RL2/IL-36R) is a ~65 kDa protein. Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways. The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway. |
| 참고 문헌 | 1. Jason E Hawkes, et al. The role of the interleukin-36 axis in generalized pustular psoriasis: a review of the mechanism of action of spesolimab. Front Immunol. 2023 Nov 21:14:1292941. [HV045016] |
| 참고사항 | For research use only. Not suitable for clinical or therapeutic use. |
SDS-PAGE for Research Grade Anti-Human IL1RL2/IL-36R (REGN6490)
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