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| 카탈로그 번호 | HS752016 |
|---|---|
| 설명 |
Anti-Human NONO (PAT-LM1) (HS752016) is a research-grade recombinant antibody targeting 54 kDa nuclear RNA- and DNA-binding protein. Produced in mammalian cells with native-like glycosylation.
Highlights
|
| 종 반응성 | Human |
| 응용 분야 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 숙주 종 | Human |
| 클론성 | Monoclonal |
| 이소타입 | IgG |
| 클론 ID | PAT-LM1 |
| 발현 시스템 | Mammalian cells |
| 타겟 | 54 kDa nuclear RNA- and DNA-binding protein, NRB54, p54nrb, NMT55, NonO protein, p54(nrb), 55 kDa nuclear protein, NONO, DNA-binding p52/p100 complex, 52 kDa subunit, Non-POU domain-containing octamer-binding protein |
| 내독소 수준 | < 10 EU/mg |
| 순도 | >95% purity as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | Q15233 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | PAT-LM1, PATLM1, PATLM1 |
| 배경 | Non-POU domain-containing octamer-binding protein (NONO) is a ~54 kDa protein. DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. 1. Zhang, Z. et al. (2001) Cell 106, 465-75. PMID: 11525732 2. Peng, R. et al. (2002) RNA (New York, N.Y.) 8, 1334-47. PMID: 12403470 3. Mircsof, D. et al. (2015) Nature neuroscience 18, 1731-6. PMID: 26571461 8. Morchikh, M. et al. (2017) Molecular cell 67, 387-399.e5. PMID: 28712728 |
| 참고사항 | For research use only. Not suitable for clinical or therapeutic use. |
SDS-PAGE for Research Grade Anti-Human NONO (PAT-LM1)
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