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| 카탈로그 번호 | HW762016 |
|---|---|
| 설명 |
Research Grade Bertilimumab (HW762016) is a human monoclonal antibody detecting Small-inducible cytokine A11 in ELISA, Bioactivity: FACS, Functional assay, Research in vivo. Suitable for Human.
Highlights
|
| 종 반응성 | Human |
| 응용 분야 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 숙주 종 | Human |
| 클론성 | Monoclonal |
| 이소타입 | IgG4-kappa |
| 발현 시스템 | Mammalian cells |
| 종 | Human |
| 타겟 | Small-inducible cytokine A11, SCYA11, Eotaxin, CCL11, Eosinophil chemotactic protein, C-C motif chemokine 11 |
| 내독소 수준 | < 10 EU/mg |
| 순도 | >95% as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | P51671 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | CAT-213, iCo-008, 375348-49-5 |
| 배경 | Eotaxin (Small-inducible cytokine A11,SCYA11,Eotaxin,CCL11,Eosinophil chemotactic protein,C-C motif chemokine 11) is a ~10 kDa protein. Chemokine that plays a central role in both allergic and non-allergic inflammatory reactions by inducing the migration of different leukocyte types including eosinophils, basophils, macrophages and dendritic cells. Exerts its effects primarily by binding to the CCR3 receptor. Induces also chemotaxis of endothelial cells and promotes angiogenesis by activating the PI3K/Akt pathway. 1. Garcia-Zepeda, EA. et al. (1996) Nature medicine 2, 449-56. PMID: 8597956 2. Wakabayashi, K. et al. (2021) Scientific reports 11, 7937. PMID: 33846499 3. Kitaura, M. et al. (1996) The Journal of biological chemistry 271, 7725-30. PMID: 8631813 4. Park, JY. et al. (2017) Journal of receptor and signal transduction research 37, 416-421. PMID: 28279120 |
| 참고사항 | For research use only. Not suitable for clinical or therapeutic use. |
| Isotype Control | Human IgG4 (S228P) Recombinant Isotype Control Antibody (13R4) (HP298207) Human IgG4 (S228P & L235E) Recombinant Isotype Control Antibody (HyHEL-10) (HP614107) Human IgG4 (S228P) Recombinant Isotype Control Antibody (SAA0184) (HP298107) |
SDS-PAGE for Research Grade Bertilimumab
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