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| 카탈로그 번호 | HF638026 |
|---|---|
| 설명 |
efdoralprin alfa (HF638026) is a research-grade recombinant antibody targeting Bone marrow serine protease.
Highlights
|
| 종 반응성 | Human |
| 응용 분야 | ELISA, Functional assay, Research in vivo |
| 클론성 | Monoclonal |
| 종 | Human |
| 타겟 | Bone marrow serine protease, EC:3.4.21.37, ELA2, ELANE, Elastase-2, HLE, Human leukocyte elastase, Medullasin, Neutrophil elastase, PMN elastase |
| 내독소 수준 | < 10 EU/mg |
| 순도 | >95% as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | P08246 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | CAS: 2539844-42-1 |
| 배경 | Neutrophil elastase (AAT) is a ~28 kDa protein. Serine protease that modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis. Promotes cleavage of GSDMB, thereby inhibiting pyroptosis. Promotes blood coagulation. Through the activation of the platelet fibrinogen receptor integrin alpha-IIb/beta-3, potentiates platelet aggregation induced by a threshold concentration of cathepsin G (CTSG). 1. Tralau, T. et al. (2004) Experimental dermatology 13, 316-25. PMID: 15140022 2. Oltra, SS. et al. (2023) Cell death and differentiation 30, 1366-1381. PMID: 36899106 3. Massberg, S. et al. (2010) Nature medicine 16, 887-96. PMID: 20676107 4. Waisberg, M. et al. (2014) PLoS pathogens 10, e1004338. PMID: 25211214 5. Si-Tahar, M. et al. (1997) The Journal of biological chemistry 272, 11636-47. PMID: 9111081 6. Belaaouaj, A. et al. (2000) Science (New York, N.Y.) 289, 1185-8. PMID: 10947984 |
| 참고사항 | For research use only. Not suitable for clinical or therapeutic use. |
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