Anti-Human Coagulation Factor XII Reference Antibody (Garadacimab, RUO) (HF664016)

Name: Anti-Human Coagulation Factor XII Reference Antibody (Garadacimab, RUO)
Brand: abinScience
SKU: HF664016
Price: 176 USD
Availability: InStock

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개요
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참고 문헌
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SDS

개요

카탈로그 번호	HF664016
설명	Garadacimab (HF664016) is a research-grade recombinant antibody targeting F12. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
종 반응성	Human
응용 분야	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
숙주 종	Human
클론성	Monoclonal
이소타입	IgG4-lambda
발현 시스템	Mammalian cells
타겟	F12, HAF, Hageman factor, Beta-factor XIIa part 2, Coagulation factor XII
내독소 수준	< 10 EU/mg
순도	>95% purity as determined by SDS-PAGE.
정제	Protein A/G purified from cell culture supernatant.
등록번호	P00748
형태	Liquid
저장 완충액	0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
대체 이름	CSL312, 2162134-62-3
배경	Coagulation factor XII (F12/Coagulationfactor XII) is a ~67 kDa protein. Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa. 1. Naito, K. et al. (1991) The Journal of biological chemistry 266, 7353-8. PMID: 2019570 2. MacQuarrie, JL. et al. (2011) Blood 117, 4134-41. PMID: 21304106 3. Brunnée, T. et al. (1993) Blood 81, 580-6. PMID: 8427954
참고사항	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG4 (S228P) Recombinant Isotype Control Antibody (SAA0184) (HP298107)

이미지

Bioactivity

SEC-HPLC detection for Research Grade Garadacimab.
SDS-PAGE

SDS-PAGE for Research Grade Garadacimab

참고 문헌

데이터시트

Anti-Human Coagulation Factor XII Reference Antibody (Garadacimab, RUO).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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Working Solution

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Anti-Human Coagulation Factor XII Reference Antibody (Garadacimab, RUO) (HF664016)

개요

이미지

참고 문헌

데이터시트

SDS

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