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| 카탈로그 번호 | JN898016 |
|---|---|
| 설명 |
Obiltoxaximab (JN898016) is a research-grade recombinant antibody targeting Protective antigen. Produced in mammalian cells with native-like glycosylation.
Highlights
|
| 종 반응성 | Bacillus anthracis |
| 응용 분야 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 숙주 종 | Chimeric |
| 클론성 | Monoclonal |
| 이소타입 | IgG1-kappa |
| 발현 시스템 | Mammalian cells |
| 타겟 | Protective antigen, PA, Anthrax toxins translocating protein, PA-83, PA83, Protective antigen PA-20, PA-20, PA20, Protective antigen PA-63, PA-63, PA63, pagA, pag, pXO1-110, BXA0164, GBAA_pXO1_0164 |
| 내독소 수준 | < 10 EU/mg |
| 순도 | >95% purity as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | P13423 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | ETI-204, 1351337-07-9 |
| 배경 | Protective antigen (PA/pagA) is a ~85 kDa protein. Protective antigen constitutes one of the three proteins composing the anthrax toxin; it mediates attachment to host cells and translocation of edema factor (EF) and lethal factor (LF) into the host cytoplasm. PA associated with LF forms the lethal toxin (LeTx) and causes death when injected; PA associated with EF forms the edema toxin (EdTx) and produces edema. PA induces immunity to infection with anthrax. 1. Bradley, KA. et al. (2001) Nature 414, 225-9. PMID: 11700562 2. Bradley, KA. et al. (2003) The Journal of biological chemistry 278, 49342-7. PMID: 14507921 3. Santelli, E. et al. (2004) Nature 430, 905-8. PMID: 15243628 4. Lacy, DB. et al. (2004) Proceedings of the National Academy of Sciences of the United States of America 101, 13147-51. PMID: 15326297 5. Singh, Y. et al. (1991) The Journal of biological chemistry 266, 15493-7. PMID: 1651334 6. Mock, M. et al. (2001) Annual review of microbiology 55, 647-71. PMID: 11544370 |
| 참고사항 | For research use only. Not suitable for clinical or therapeutic use. |
SEC-HPLC detection for Research Grade Obiltoxaximab.
Detects PA/pagA/PA-83 in indirect ELISAs.
SDS-PAGE for Research Grade Obiltoxaximab
Western blot analysis was performed using anti-PA/pagA/PA-83 monoclonal antibody at 1μg/ml on various samples.
Lane 1: recombinant Bacillus anthracis PA/pagA/PA-83(Catalog No: JN898012), 50ng
Lane 2: recombinant Bacillus anthracis PA/pagA/PA-83(Catalog No: JN898012), 30ng
Lane 3: recombinant Bacillus anthracis PA/pagA/PA-83(Catalog No: JN898012), 20ng
Lane 4: recombinant Bacillus anthracis PA/pagA/PA-83(Catalog No: JN898012), 10ng
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