Anti-Human MAdCAM-1 Reference Antibody (Ontamalimab, RUO) (HC589016)

Name: Anti-Human MAdCAM-1 Reference Antibody (Ontamalimab, RUO)
Brand: abinScience
SKU: HC589016
Price: 176 USD
Availability: InStock

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개요
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참고 문헌
데이터시트
SDS

개요

카탈로그 번호	HC589016
설명	Ontamalimab (HC589016) is a research-grade recombinant antibody targeting MAdCAM-1. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
종 반응성	Human
응용 분야	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
숙주 종	Human
클론성	Monoclonal
이소타입	IgG2-kappa
발현 시스템	Mammalian cells
타겟	MAdCAM-1, hMAdCAM-1, MADCAM1, Mucosal addressin cell adhesion molecule 1
내독소 수준	< 10 EU/mg
순도	>95% purity as determined by SDS-PAGE.
정제	Protein A/G purified from cell culture supernatant.
등록번호	Q13477
형태	Liquid
저장 완충액	0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
대체 이름	PF-00547659, PF-547659, SHP647, 2098790-40-8
배경	Mucosal addressin cell adhesion molecule 1 (MADCAM1) is a ~40 kDa protein. Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.
참고사항	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

이미지

SEC-HPLC

SEC-HPLC detection for Research Grade Ontamalimab.
Bioactivity

Detects MADCAM1 in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Research Grade Ontamalimab.

참고 문헌

데이터시트

Anti-Human MAdCAM-1 Reference Antibody (Ontamalimab, RUO).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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Formula

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Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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Anti-Human MAdCAM-1 Reference Antibody (Ontamalimab, RUO) (HC589016)

개요

이미지

참고 문헌

데이터시트

SDS

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