Anti-Human Nogo Reference Antibody (Ozanezumab, RUO) (HP021016)

Name: Anti-Human Nogo Reference Antibody (Ozanezumab, RUO)
Brand: abinScience
SKU: HP021016
Price: 176 USD
Availability: InStock

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개요
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참고 문헌
데이터시트
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개요

카탈로그 번호	HP021016
설명	Ozanezumab (HP021016) is a research-grade recombinant antibody targeting RTN-x. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
종 반응성	Human
응용 분야	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
숙주 종	Human
클론성	Monoclonal
이소타입	IgG1-nd
발현 시스템	Mammalian cells
타겟	RTN-x, Reticulon-4, Neuroendocrine-specific protein, Neuroendocrine-specific protein C homolog, NOGO, Nogo protein, Neurite outgrowth inhibitor, NSP, Reticulon-5, KIAA0886, RTN4, Foocen
내독소 수준	< 10 EU/mg
순도	>95% purity as determined by SDS-PAGE.
정제	Protein A/G purified from cell culture supernatant.
등록번호	Q9NQC3
형태	Liquid
저장 완충액	0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
대체 이름	GSK-1223249, 1310680-64-8
배경	Reticulon-4 (RTN4) is a ~129 kDa protein. Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules. They regulate membrane morphogenesis in the ER by promoting tubular ER production. They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins. However each isoform have specific functions mainly depending on their tissue expression specificities (Probable). 1. Yamamoto, Y. et al. (2014) The Biochemical journal 458, 69-79. PMID: 24262037 2. Urade, T. et al. (2014) The Kobe journal of medical sciences 60, E57-65. PMID: 25612671 3. Wang, S. et al. (2016) eLife 5. PMID: 27619977 4. Rämö, O. et al. (2016) Scientific reports 6, 35969. PMID: 27786289 5. Christodoulou, A. et al. (2016) Journal of cell science 129, 1552-65. PMID: 26906412
참고사항	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (HyHEL-10) (HV080407) Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)