Anti-Tityus serrulatus Tityustoxin VII Reference Antibody (Serrumab, RUO) (HP769016)

Name: Anti-Tityus serrulatus Tityustoxin VII Reference Antibody (Serrumab, RUO)
Brand: abinScience
SKU: HP769016
Price: 326 USD
Availability: InStock

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개요

카탈로그 번호	HP769016
설명	Serrumab (HP769016) is a research-grade recombinant antibody targeting Tityustoxin VIIToxin VIITs7. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
종 반응성	Tityus serrulatus (Brazilian scorpion)
응용 분야	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
숙주 종	Human
클론성	Monoclonal
이소타입	IgG1, kappa
발현 시스템	Mammalian cells
타겟	Tityustoxin VIIToxin VIITs7
내독소 수준	< 10 EU/mg
순도	>95% purity as determined by SDS-PAGE.
정제	Protein A/G purified from cell culture supernatant.
등록번호	P15226
형태	Liquid
저장 완충액	0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
배경	Beta-mammal/insect toxin Ts1 (Tityustoxin VIIToxin VIITs7) is a ~9 kDa protein. Voltage-gated sodium channels (Nav) gating-modifier. Acts both as alpha- and beta-toxin, since it affects not only activation but also inactivation of Nav channels (Probable). Binds to Nav domain DII and impairs the four Nav channel voltage sensors movements. Depending on Nav channel subtypes tested, can also bind Nav domains DIII (low affinity) and DIV (very low affinity). Acts on almost all the Nav channels tested (mammalian Nav1.2/SCN2A, Nav1.3/SCN3A, Nav1.4/SCN4A, Nav1.5/SCN5A, Nav1.6/SCN8A, Nav1.9/SCN11A, and insect DmNav1). 1. Peigneur, S. et al. (2015) Neuropharmacology 95, 269-77. PMID: 25862296 2. Campos, FV. et al. (2007) The Journal of general physiology 130, 257-68. PMID: 17698594 3. Bosmans, F. et al. (2008) Nature 456, 202-8. PMID: 19005548 4. Martin-Eauclaire, MF. et al. (2015) The Journal of general physiology 145, 155-62. PMID: 25624450 5. Bosmans, F. et al. (2011) The Journal of general physiology 138, 59-72. PMID: 21670206 6. Dang, B. et al. (2014) Angewandte Chemie (International ed. in English) 53, 8970-4. PMID: 24989851
참고사항	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE

SDS-PAGE for Research Grade Serrumab.

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Anti-Tityus serrulatus Tityustoxin VII Reference Antibody (Serrumab, RUO).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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Mass

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C₁ × V₁ = C₂ × V₂

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C₁ (Stock Conc.)

V₁ (Stock Vol.)

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C₂ (Working Conc.)

V₂ (Working Vol.)

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Anti-Tityus serrulatus Tityustoxin VII Reference Antibody (Serrumab, RUO) (HP769016)

개요

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