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| 카탈로그 번호 | VK705016 |
|---|---|
| 설명 |
Sevirumab (VK705016) is a research-grade recombinant antibody targeting Envelope glycoprotein H. Produced in mammalian cells with native-like glycosylation.
Highlights
|
| 종 반응성 | Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5) |
| 응용 분야 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 숙주 종 | Human |
| 클론성 | Monoclonal |
| 이소타입 | IgG1, kappa |
| 발현 시스템 | Mammalian cells |
| 타겟 | Envelope glycoprotein H, gH, gH, UL75 |
| 내독소 수준 | < 10 EU/mg |
| 순도 | >95% purity as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | P12824 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | EV27, MSL109, SDZMSL109, 138660-96-5 |
| 배경 | Envelope glycoprotein H (gHUL75) is a ~84 kDa protein. The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis. In human cytomegalovirus, forms two distinct complexes to mediate viral entry, a trimer and a pentamer at the surface of the virion envelope. The gH-gL-gO trimer is required for infection in fibroblasts by interacting with host PDGFRA, and in glioblastoma cells by interacting with host EPHA2. |
| 참고사항 | For research use only. Not suitable for clinical or therapeutic use. |
SEC-HPLC detection for Research Grade Sevirumab.
SDS-PAGE for Research Grade Sevirumab.
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