Anti-Human TRAIL R2/TNFRSF10B Reference Antibody (Tigatuzumab, RUO) (HT348026)

Name: Anti-Human TRAIL R2/TNFRSF10B Reference Antibody (Tigatuzumab, RUO)
Brand: abinScience
SKU: HT348026
Price: 176 USD
Availability: InStock

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100ug
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5mg
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25mg
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개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호	HT348026
설명	Tigatuzumab (HT348026) is a research-grade recombinant antibody targeting CD262. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
종 반응성	Human
응용 분야	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
숙주 종	Human
클론성	Monoclonal
이소타입	IgG1-nd
테스트된 응용 분야	WB
타겟	CD262, DR5, Death receptor 5, KILLER, TNF-related apoptosis-inducing ligand receptor 2, TNFRSF10B, TRAIL receptor 2, TRAIL-R2, TRAILR2, TRICK2, Tumor necrosis factor receptor superfamily member 10B, ZTNFR9
내독소 수준	< 10 EU/mg
순도	>95% as determined by SDS-PAGE.
정제	Protein A/G purified from cell culture supernatant.
등록번호	O14763
형태	Liquid
저장 완충액	0.01M PBS pH 7.4. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
대체 이름	CS-1008, TRA-8, 918127-53-4
배경	Tumor necrosis factor receptor superfamily member 10B (CD262/TRAIL-R2) is a ~47 kDa protein. Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. 1. Hymowitz, SG. et al. (1999) Molecular cell 4, 563-71. PMID: 10549288
참고사항	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

이미지

SEC-HPLC

SEC-HPLC detection for Research Grade Tigatuzumab.
Bioactivity

Detects CD262/TNFRSF10B/TRAIL-R2/DR5 in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Research Grade Tigatuzumab.
Western blot

Western blot analysis was performed using anti-CD262 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human CD262 (Catalog No: HT348011)
Lane 2: negative control