Anti-Human TRAIL R2/TNFRSF10B Reference Antibody (Zaptuzumab, RUO) (HT348156)

Name: Anti-Human TRAIL R2/TNFRSF10B Reference Antibody (Zaptuzumab, RUO)
Brand: abinScience
SKU: HT348156
Price: 176 USD
Availability: InStock

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가격(USD):

사양:

100ug
1mg
5mg
10mg
25mg
50mg
100mg

수량:

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HT348156

설명

Zaptuzumab (HT348156) is a research-grade recombinant antibody targeting CD262.

Highlights

●Research Grade — For PK/PD studies, assay development, and ADA research.

종 반응성

Human

응용 분야

ELISA, FCM, Functional assay

숙주 종

Human

클론성

Monoclonal

타겟

CD262, DR5, Death receptor 5, KILLER, TNF-related apoptosis-inducing ligand receptor 2, TNFRSF10B, TRAIL receptor 2, TRAIL-R2, TRAILR2, TRICK2, Tumor necrosis factor receptor superfamily member 10B, ZTNFR9

내독소 수준

< 10 EU/mg

순도

>95% as determined by SDS-PAGE.

정제

Protein A/G purified from cell culture supernatant.

등록번호

O14763

형태

Liquid

저장 완충액

0.01M PBS pH 7.4.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:2000-1:20000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Tumor necrosis factor receptor superfamily member 10B (DR5) is a ~47 kDa protein. Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.

1. Hymowitz, SG. et al. (1999) Molecular cell 4, 563-71. PMID: 10549288

참고사항

For research use only.

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