Varlilumab ELISA Kit (DB796018)

데이터시트 제품 공유 정보 복사

개요
이미지
참고 문헌
데이터시트
SDS

카탈로그 번호	DB796018
설명	Varlilumab ELISA Kit (DB796018) — Quantitative sandwich ELISA for Varlilumab. Sample: Plasma, Serum. Range: 0.31-5 μg/mL. Sensitivity: 0.156 μg/ml. Highlights ●Sandwich Format — High specificity, reliable quantification. ●High Sensitivity — Optimized for low-abundance target detection. ●Ready-to-Use — Complete kit with pre-coated plates included.
샘플 유형	Plasma, Serum
민감도	0.156 μg/ml
범위	0.31-5 μg/mL
등록번호	P26842
응용 분야	ELISA
검출 방법	Colorimetric
분석 유형	Quantitative
회수율	80-120%
배송	2-8 ℃
안정성 및 저장	The stability of ELISA kit is determined by the loss rate of activity. The loss rate of this kit is less than 20% prior to the expiration date under appropriate storage condition.
사양	Varlilumab
대체 이름	1F5, CDX-1127, 1393344-72-3
배경	CD27 antigen (Varlilumab) is a ~29 kDa protein. Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B-cells. The CD70-CD27 signaling pathway mediates antigen-specific T-cell activation and expansion which in turn provides immune surveillance of B-cells. Mechanistically, CD70 ligation activates the TRAF2-PTPN6 axis that subsequently inhibits LCK phosphorylation to promote phenotypic and transcriptional adaptations of T-cell memory. In addition, activation by CD70 on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation and thus modulates hematopoiesis. Negatively regulates the function of Th2 lymphocytes in the adipose tissue. 1. Izawa, K. et al. (2017) The Journal of experimental medicine 214, 73-89. PMID: 28011863 2. Jaeger-Ruckstuhl, CA. et al. (2024) Immunity 57, 287-302.e12. PMID: 38354704
참고사항	For Research Use Only.