Fungal Allergen Research Reagents

Fungal (mold) sensitization is an underrecognized driver of severe asthma and allergic bronchopulmonary aspergillosis (ABPA). Alternaria alternata (Alt a 1) is the most clinically important outdoor mold allergen, strongly associated with severe and life-threatening asthma exacerbations. Aspergillus fumigatus allergens (Asp f 1–6) define the spectrum from simple IgE sensitization to ABPA, a complex allergic-immunologic lung disease requiring distinct management. Recombinant fungal allergens enable component-resolved diagnosis of mold allergy and differentiation of ABPA from simple Aspergillus sensitization.

Research Use Only (RUO)Not intended for diagnostic or therapeutic procedures.

abinScience provides recombinant fungal allergen proteins and detection antibodies covering the major allergenic mold genera. All products are manufactured by our parent company AtaGenix Laboratories under ISO quality systems. Browse products below or contact us for custom development.

Key Fungal Allergens

Alt a 1 (Alternaria alternata) — The major Alternaria allergen, a unique dimeric protein with no known homologs. Alt a 1 sensitization is recognized by >90% of Alternaria-allergic patients and is a strong independent risk factor for severe asthma, near-fatal asthma episodes, and thunderstorm asthma outbreaks. Recombinant Alt a 1 is the key diagnostic component for Alternaria sensitization.
→ Browse Alt a allergen proteins

Asp f 1 / Asp f 2 / Asp f 3 / Asp f 6 (Aspergillus fumigatus) — Aspergillus allergens define the clinical spectrum from simple sensitization to ABPA. Asp f 1 (ribotoxin) and Asp f 3 (peroxisomal protein) indicate simple Aspergillus sensitization; Asp f 4 and Asp f 6 are secreted allergens associated with ABPA and indicate fungal colonization. This CRD pattern (Asp f 1/3 positive vs Asp f 4/6 positive) differentiates simple sensitization from ABPA, guiding antifungal and corticosteroid therapy decisions.
→ Browse Asp f allergen proteins

Cla h (Cladosporium herbarum) / Pen ch (Penicillium chrysogenum) — Additional outdoor (Cladosporium) and indoor (Penicillium) mold allergens. Cladosporium is the most abundant airborne mold worldwide but less clinically severe than Alternaria. Penicillium sensitization is associated with damp indoor environments and sick building syndrome.
→ Browse Cla h / Pen ch allergen proteins

References

1. Agarwal R, et al. Allergic bronchopulmonary aspergillosis: review of literature and proposal of new diagnostic and classification criteria. Clin Exp Allergy. 2013;43(8):850-873. DOI

2. Gabriel MF, et al. Alternaria alternata allergens: markers of exposure, phylogeny and risk of fungal infection. Environ Int. 2016;89-90:71-80. DOI