Anti-ESR1/ER-alpha Polyclonal Antibody (HY335014)

Name: Anti-ESR1/ER-alpha Polyclonal Antibody
Brand: abinScience
SKU: HY335014
Price: 168 USD
Availability: InStock

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개요
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SDS

개요

카탈로그 번호

HY335014

설명

Anti-ESR1/ER-alpha Polyclonal Antibody (HY335014) is a rabbit polyclonal antibody detecting ER-alpha in ELISA, IHC, WB. Suitable for Human, Mouse, Cat, Rat, and Anolis carolinensis.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human ESR1/ER-alpha (Met297-Ser554).

타겟

Estrogen receptor, ER-alpha, ESR, ER, ESR1, Nuclear receptor subfamily 3 group A member 1, NR3A1, Estradiol receptor

정제

Purified by antigen affinity column.

등록번호

P03372

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Estrogen receptor (ESR1/ER-alpha) is a ~66 kDa protein. Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner.

1. Molli, PR. et al. (2008) Oncogene 27, 1971-80. PMID: 17922032

참고사항

For research use only.

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