Anti-Human ESR1/ER-alpha Recombinant Antibody (RB125) (HY335013)

Name: Anti-Human ESR1/ER-alpha Recombinant Antibody (RB125)
Brand: abinScience
SKU: HY335013
Price: 191 USD
Availability: InStock

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50ug
100ug
1mg

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HY335013

Species reactivity

Human

Applications

ELISA, IF

Host species

Mouse

Isotype

IgG2a

Clone ID

RB125

Clonality

Monoclonal

Target

ESR1, NR3A1, Estrogen receptor, ER-alpha, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P03372

RRID

Anti-Human ESR1/ER-alpha Antibody (RB125) (abinScience Cat# HY335013, RRID:AB_3729466)

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Estrogen receptor (ESR1/ER-alpha) is a ~66 kDa protein. Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner.

1. Molli, PR. et al. (2008) Oncogene 27, 1971-80. PMID: 17922032

Note

For research use only.

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