Anti-Human ANO1 Monoclonal Antibody (1A608) (HP641035)

Name: Anti-Human ANO1 Monoclonal Antibody (1A608)
Brand: abinScience
SKU: HP641035
Price: 106 USD
Availability: InStock

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개요

카탈로그 번호	HP641035
설명	Anti-Human ANO1 Monoclonal Antibody (1A608) [1A608] (HP641035) is a mouse monoclonal antibody detecting ANO1 in ELISA, IHC, WB. Suitable for Human. Highlights ●Recombinant — Superior batch-to-batch reproducibility with defined sequences. ●Multi-Application — Validated across multiple applications.
종 반응성	Human
응용 분야	ELISA, IHC, WB
숙주 종	Mouse
클론성	Monoclonal
이소타입	IgG
클론 ID	1A608
면역원	E. coli - derived recombinant human ANO1 (Met117-Gly325).
타겟	Anoctamin-1, Discovered on gastrointestinal stromal tumors protein 1, Oral cancer overexpressed protein 2, Transmembrane protein 16A, Tumor-amplified and overexpressed sequence 2, ANO1
정제	Protein A/G purified from cell culture supernatant.
등록번호	Q5XXA6
형태	Liquid
저장 완충액	0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
배경	Anoctamin-1 (ANO1) is a ~114 kDa protein. Calcium-activated chloride channel (CaCC). Plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. Required for CFTR activation by enhancing endoplasmic reticulum Ca(2+) store release and is also required for CFTR membrane expression. 1. Schreiber, R. et al. (2010) The Journal of biological chemistry 285, 7838-45. PMID: 20056604 2. Ousingsawat, J. et al. (2011) Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 28, 715-24. PMID: 22178883 3. Tian, Y. et al. (2012) Journal of cell science 125, 4991-8. PMID: 22946059 4. Park, JH. et al. (2021) Journal of medical genetics 58, 247-253. PMID: 32487539 5. Benedetto, R. et al. (2017) Scientific reports 7, 12397. PMID: 28963502 6. Cabrita, I. et al. (2021) American journal of respiratory cell and molecular biology 64, 50-58. PMID: 33026825 7. Simões, FB. et al. (2019) Life science alliance 2. PMID: 31732694
참고사항	For research use only.