Anti-Human C9orf72 Recombinant Antibody (SAA1886) (HA376013)

Name: Anti-Human C9orf72 Recombinant Antibody (SAA1886)
Brand: abinScience
SKU: HA376013
Price: 196 USD
Availability: InStock

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가격(USD):

사양:

50ug
100ug
1mg

수량:

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개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호

HA376013

종 반응성

Human

응용 분야

ELISA

숙주 종

Mouse

클론성

Monoclonal

이소타입

IgG2a, kappa

클론 ID

SAA1886

타겟

Guanine nucleotide exchange C9orf72, C9orf72

내독소 수준

Please contact with the lab for this information.

순도

>95% as determined by SDS-PAGE.

정제

Protein A/G purified from cell culture supernatant.

등록번호

Q96LT7

RRID

Anti-Human C9orf72 Antibody (SAA1886) (abinScience Cat# HA376013, RRID:AB_3727650)
_x005F_x005F_x000D_

형태

Liquid

저장 완충액

0.01M PBS pH 7.4

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:2000-1:20000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

배경

Guanine nucleotide exchange factor C9orf72 is a ~54 kDa protein. Acts as a guanine-nucleotide releasing factor (GEF) for Rab GTPases by promoting the conversion of inactive RAB-GDP to the active form RAB-GTP. Acts as a GEF for RAB39A which enables HOPS-mediated autophagosome-lysosome membrane tethering and fusion in mammalian autophagy. Component of the C9orf72-SMCR8 complex where both subunits display GEF activity and that regulates autophagy. As part of the C9orf72-SMCR8-WDR41 (CSW) complex, functions as GEF for RAB8A and RAB39B, thereby promoting autophagosome maturation. As part of the C9orf72-SMCR8 complex, also functions as GTPase activating protein (GAP) for RAB8A and RAB11A in vitro.

1. Sellier, C. et al. (2016) The EMBO journal 35, 1276-97. PMID: 27103069

2. Sullivan, PM. et al. (2016) Acta neuropathologica communications 4, 51. PMID: 27193190

3. Yang, M. et al. (2016) Science advances 2, e1601167. PMID: 27617292

4. Jung, J. et al. (2017) eLife 6. PMID: 28195531

5. Zhang, S. et al. (2023) Nature communications 14, 6360. PMID: 37821429

참고사항

For research use only.

이미지

SDS-PAGE

SDS-PAGE for Anti-Human C9orf72 Antibody (SAA1886)

참고 문헌

데이터시트

Anti-Human C9orf72 Recombinant Antibody (SAA1886).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human C9orf72 Recombinant Antibody (SAA1886) (HA376013)

개요

이미지

참고 문헌

데이터시트

SDS

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