Anti-Human CD169/SIGLEC1 Polyclonal Antibody (HV234014)

Name: Anti-Human CD169/SIGLEC1 Polyclonal Antibody
Brand: abinScience
SKU: HV234014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
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개요

카탈로그 번호

HV234014

설명

Anti-Human CD169/SIGLEC1 Polyclonal Antibody (HV234014) is a rabbit polyclonal antibody detecting CD169/SIGLEC1 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human CD169/SIGLEC1 (Gly34-Gly240).

타겟

Siglec-1, CD169, SIGLEC1, SN, Sialic acid-binding Ig-like lectin 1, Sialoadhesin

정제

Purified by antigen affinity column.

등록번호

Q9BZZ2

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Sialoadhesin (CD169/SIGLEC1) is a ~182 kDa protein. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Plays a crucial role in limiting bacterial dissemination by engaging sialylated bacteria to promote effective phagocytosis and antigen presentation for the adaptive immune response. Mediates the uptake of various enveloped viruses via sialic acid recognition and subsequently induces the formation of intracellular compartments filled with virions (VCCs). In turn, enhances macrophage-to-T-cell transmission of several viruses including HIV-1 or SARS-CoV-2. Acts as an endocytic receptor mediating clathrin dependent endocytosis.

1. Jones, C. et al. (2003) Molecular microbiology 49, 1213-25. PMID: 12940982

2. Benet, S. et al. (2021) Journal of extracellular vesicles 10, e12046. PMID: 33489013

3. Hammonds, JE. et al. (2017) PLoS pathogens 13, e1006181. PMID: 28129379

4. Perez-Zsolt, D. et al. (2021) Cellular & molecular immunology 18, 2676-2678. PMID: 34782760

5. Zheng, Q. et al. (2015) Cell research 25, 1121-36. PMID: 26358190

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-Human CD169/SIGLEC1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human CD169/SIGLEC1 Polyclonal Antibody (HV234014)

개요

이미지

참고 문헌

데이터시트

SDS