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| 카탈로그 번호 | HB681137 |
|---|---|
| 종 반응성 | Human |
| 응용 분야 | FCM |
| 숙주 종 | Human |
| 클론성 | Monoclonal |
| 이소타입 | IgG1, kappa |
| 클론 ID | SAA0126 |
| 접합 | APC |
| 타겟 | HEK, Eph-like tyrosine kinase 1, EK4, EPHA3, Tyrosine-protein kinase receptor ETK1, Tyrosine-protein kinase TYRO4, Ephrin type-A receptor 3, hEK4, ETK, TYRO4, ETK1, Human embryo kinase, EPH-like kinase 4 |
| 내독소 수준 | Please contact with the lab for this information. |
| 관련 제품 | Human IgG1 Recombinant Isotype Control Antibody (HyHEL-10), APC |
| 등록번호 | P29320 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| 배경 | Ephrin type-A receptor 3 (EPHA3) is a ~110 kDa protein. Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Also activated by EFNA1, inhibiting epithelial-to-mesenchymal transition of cardiac cells and playing a role in heart development. 1. Lawrenson, ID. et al. (2002) Journal of cell science 115, 1059-72. PMID: 11870224 2. Sharfe, N. et al. (2003) Journal of immunology (Baltimore, Md. : 1950) 170, 6024-32. PMID: 12794130 |
| 참고사항 | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |
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