Anti-Human INPP5D Monoclonal Antibody (1A540) (HP060015)

Name: Anti-Human INPP5D Monoclonal Antibody (1A540)
Brand: abinScience
SKU: HP060015
Price: 106 USD
Availability: InStock

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개요

카탈로그 번호	HP060015
설명	Anti-Human INPP5D Monoclonal Antibody (1A540) [1A540] (HP060015) is a mouse monoclonal antibody detecting INPP5D in ELISA, IHC, WB. Suitable for Human. Highlights ●Recombinant — Superior batch-to-batch reproducibility with defined sequences. ●Multi-Application — Validated across multiple applications.
종 반응성	Human
응용 분야	ELISA, IHC, WB
숙주 종	Mouse
클론성	Monoclonal
이소타입	IgG
클론 ID	1A540
면역원	E. coli - derived recombinant human INPP5D (Pro298-Gly711).
타겟	Phosphatidylinositol 345-trisphosphate 5-phosphatase 1, EC:3.1.3.86, Inositol polyphosphate-5-phosphatase D, EC:3.1.3.56, Inositol polyphosphate-5-phosphatase of 145 kDa, SIP-145, Phosphatidylinositol 45-bisphosphate 5-phosphatase, EC:3.1.3.36, SH2 domain-containing inositol 5'-phosphatase 1, SH2 domain-containing inositol phosphatase 1, SHIP-1, p150Ship, hp51CN, INPP5D
정제	Protein A/G purified from cell culture supernatant.
등록번호	Q92835
형태	Liquid
저장 완충액	0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
배경	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (INPP5D) is a ~133 kDa protein. Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. 1. Kisseleva, MV. et al. (2000) The Journal of biological chemistry 275, 20110-6. PMID: 10764818 2. Kavanaugh, WM. et al. (1996) Current biology : CB 6, 438-45. PMID: 8723348 3. Drayer, AL. et al. (1996) Biochemical and biophysical research communications 225, 243-9. PMID: 8769125 4. Odai, H. et al. (1997) Blood 89, 2745-56. PMID: 9108392 5. Vaillancourt, M. et al. (2006) Cellular signalling 18, 2022-32. PMID: 16682172
참고사항	For research use only.