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| 카탈로그 번호 | HC295013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | ELISA | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a, kappa | ||||
| 클론 ID | SAA1945 | ||||
| 타겟 | KIAA0070, KARS, Lysyl-tRNA synthetase, LysRS, Lysine--tRNA ligase, KARS1 | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | Q15046 | ||||
| RRID | Anti-Human KARS1/Lysyl-tRNA synthetase Antibody (SAA1945) (abinScience Cat# HC295013, RRID:AB_3727709) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Lysine--tRNA ligase (KARS1) is a ~68 kDa protein. Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity. 1. Guzzo, CM. et al. (2008) Biochemical and biophysical research communications 365, 718-23. PMID: 18029264 2. Guo, M. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 2331-6. PMID: 18272479 3. Shiba, K. et al. (1997) The Journal of biological chemistry 272, 22809-16. PMID: 9278442 4. Park, SG. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 6356-61. PMID: 15851690 5. Lee, YN. et al. (2004) Immunity 20, 145-51. PMID: 14975237 6. Yannay-Cohen, N. et al. (2009) Molecular cell 34, 603-11. PMID: 19524539 7. Ofir-Birin, Y. et al. (2013) Molecular cell 49, 30-42. PMID: 23159739 8. Zamecnik, PC. et al. (1966) Biochemical and biophysical research communications 24, 91-7. PMID: 5338216 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human KARS1/Lysyl-tRNA synthetase Antibody (SAA1945)
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