Anti-Human Lysyl-tRNA Synthetase Reference Antibody (Rapaprutug, RUO) (HC295016)

Name: Anti-Human Lysyl-tRNA Synthetase Reference Antibody (Rapaprutug, RUO)
Brand: abinScience
SKU: HC295016
Price: 370 USD
Availability: InStock

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Overview

Catalog No.	HC295016
Description	rapaprutug (HC295016) is a research-grade recombinant antibody targeting KARS1/Lysyl-tRNA synthetase. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research.
Species reactivity	Human
Applications	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
Host species	Human
Clonality	Monoclonal
Isotype	IgG1, Kappa
Expression system	Mammalian cells
Nature	Recombinant
Target	KARS1/Lysyl-tRNA synthetase
Endotoxin level	< 10 EU/mg as determined by LAL method.
Purity	>95% as determined by SDS-PAGE.
Accession	Q15046
Form	Liquid
Storage buffer	0.01M PBS pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	2994192-38-8
Background	Lysine--tRNA ligase (KARS1/Lysyl-tRNA synthetase) is a ~68 kDa protein. Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity. 1. Guzzo, CM. et al. (2008) Biochemical and biophysical research communications 365, 718-23. PMID: 18029264 2. Guo, M. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 2331-6. PMID: 18272479 3. Shiba, K. et al. (1997) The Journal of biological chemistry 272, 22809-16. PMID: 9278442 4. Park, SG. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 6356-61. PMID: 15851690 5. Lee, YN. et al. (2004) Immunity 20, 145-51. PMID: 14975237 6. Yannay-Cohen, N. et al. (2009) Molecular cell 34, 603-11. PMID: 19524539 7. Ofir-Birin, Y. et al. (2013) Molecular cell 49, 30-42. PMID: 23159739 8. Zamecnik, PC. et al. (1966) Biochemical and biophysical research communications 24, 91-7. PMID: 5338216
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE for Research Grade rapaprutug

References

Datasheet

Anti-Human Lysyl-tRNA Synthetase Reference Antibody (Rapaprutug, RUO).pdf

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Formula

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Recombinant Proteins

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Anti-Human Lysyl-tRNA Synthetase Reference Antibody (Rapaprutug, RUO) (HC295016)

Overview

Images

References

Datasheet

SDS