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| 카탈로그 번호 | HC573107 |
|---|---|
| 종 반응성 | Human |
| 응용 분야 | Blocking, ELISA, FCM |
| 숙주 종 | Mouse |
| 클론성 | Monoclonal |
| 이소타입 | IgG2a, kappa |
| 클론 ID | SAA0543 |
| 타겟 | GARP, Leucine-rich repeat-containing protein 32, Glycoprotein A repetitions predominant, D11S833E, Garpin, Transforming growth factor beta activator LRRC32, LRRC32 |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >95% as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | Q14392 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS, pH 7.4, 0.09% Sodium azide. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 배경 | Transforming growth factor beta activator LRRC32 (GARP) is a ~71 kDa protein. Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta. Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3). 1. Tran, DQ. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 13445-50. PMID: 19651619 2. Stockis, J. et al. (2009) European journal of immunology 39, 3315-22. PMID: 19750484 3. Wang, R. et al. (2012) Molecular biology of the cell 23, 1129-39. PMID: 22278742 |
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human LRRC32/GARP Antibody (SAA0543)
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
