Anti-Human LRRC32/GARP Recombinant Antibody (SAA0543), PE (HC573127)

Name: Anti-Human LRRC32/GARP Recombinant Antibody (SAA0543), PE
Brand: abinScience
SKU: HC573127
Price: 256 USD
Availability: InStock

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Overview

Catalog No.	HC573127
Species reactivity	Human
Applications	ELISA, FCM
Host species	Mouse
Isotype	IgG2a, kappa
Clone ID	SAA0543
Conjugation	PE
Clonality	Monoclonal
Target	GARP, Leucine-rich repeat-containing protein 32, Glycoprotein A repetitions predominant, D11S833E, Garpin, Transforming growth factor beta activator LRRC32, LRRC32
Endotoxin level	Please contact with the lab for this information.
Associated products	Mouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173), PE
Accession	Q14392
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	Transforming growth factor beta activator LRRC32 (GARP) is a ~71 kDa protein. Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta. Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3). 1. Tran, DQ. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 13445-50. PMID: 19651619 2. Stockis, J. et al. (2009) European journal of immunology 39, 3315-22. PMID: 19750484 3. Wang, R. et al. (2012) Molecular biology of the cell 23, 1129-39. PMID: 22278742
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Human LRRC32/GARP Recombinant Antibody (SAA0543), PE.pdf

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Anti-Human LRRC32/GARP Recombinant Antibody (SAA0543), PE (HC573127)

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