Anti-Human LRRC32/GARP Recombinant Antibody (SAA0543) (HC573107)

Name: Anti-Human LRRC32/GARP Recombinant Antibody (SAA0543)
Brand: abinScience
SKU: HC573107
Price: 196 USD
Availability: InStock

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Overview

Catalog No.	HC573107
Species reactivity	Human
Applications	Blocking, ELISA, FCM
Host species	Mouse
Isotype	IgG2a, kappa
Clone ID	SAA0543
Clonality	Monoclonal
Target	GARP, Leucine-rich repeat-containing protein 32, Glycoprotein A repetitions predominant, D11S833E, Garpin, Transforming growth factor beta activator LRRC32, LRRC32
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q14392
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.09% Sodium azide. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Transforming growth factor beta activator LRRC32 (GARP) is a ~71 kDa protein. Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta. Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3). 1. Tran, DQ. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 13445-50. PMID: 19651619 2. Stockis, J. et al. (2009) European journal of immunology 39, 3315-22. PMID: 19750484 3. Wang, R. et al. (2012) Molecular biology of the cell 23, 1129-39. PMID: 22278742
Note	For research use only.

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SDS-PAGE for Anti-Human LRRC32/GARP Antibody (SAA0543)

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Anti-Human LRRC32/GARP Recombinant Antibody (SAA0543).pdf

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Anti-Human LRRC32/GARP Recombinant Antibody (SAA0543) (HC573107)

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