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| 카탈로그 번호 | HW821035 |
|---|---|
| 설명 |
Anti-Human PSEN2 Monoclonal Antibody (1A531) [1A531] (HW821035) is a mouse monoclonal antibody detecting PSEN2 in ELISA, IHC, WB. Suitable for Human.
Highlights
|
| 종 반응성 | Human |
| 응용 분야 | ELISA, IHC, WB |
| 숙주 종 | Mouse |
| 클론성 | Monoclonal |
| 이소타입 | IgG |
| 클론 ID | 1A531 |
| 면역원 | E. coli - derived recombinant human PSEN2 (Lys271-Lys361). |
| 타겟 | Presenilin-2, PS-2, EC:3.4.23.-, AD3LP, AD5, E5-1, STM-2, Presenilin-2 NTF subunit, Presenilin-2 CTF subunit, PSEN2 |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >95% as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | P49810 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 배경 | Presenilin-2 (PSEN2) is a ~50 kDa protein. Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Selectively cleaves late endosomal/lysosomal localized substrates and generates the prominent pool of intracellular amyloid beta that contains longer amyloid beta. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria. 1. Steiner, H. et al. (1999) The Journal of biological chemistry 274, 28669-73. PMID: 10497236 2. Kimberly, WT. et al. (2000) The Journal of biological chemistry 275, 3173-8. PMID: 10652302 3. Kumar-Singh, S. et al. (2006) Human mutation 27, 686-95. PMID: 16752394 4. Sannerud, R. et al. (2016) Cell 166, 193-208. PMID: 27293189 5. Guo, X. et al. (2022) Nature communications 13, 6299. PMID: 36272978 6. Tu, H. et al. (2006) Cell 126, 981-93. PMID: 16959576 7. Zampese, E. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 2777-82. PMID: 21285369 |
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human PSEN2 Monoclonal Antibody (1A531)
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