Anti-Human R-Spondin 2 Recombinant Antibody (SAA1853) (HA089013)

Name: Anti-Human R-Spondin 2 Recombinant Antibody (SAA1853)
Brand: abinScience
SKU: HA089013
Price: 196 USD
Availability: InStock

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가격(USD):

사양:

50ug
100ug
1mg

수량:

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개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호

HA089013

종 반응성

Human

응용 분야

ELISA

숙주 종

Mouse

클론성

Monoclonal

이소타입

IgG2a, kappa

클론 ID

SAA1853

타겟

Roof plate-specific spondin-2, R-spondin-2, hRspo2, RSPO2

내독소 수준

< 10 EU/mg

순도

>95% as determined by SDS-PAGE.

정제

Protein A/G purified from cell culture supernatant.

등록번호

Q6UXX9

RRID

Anti-Human RSPO2 Antibody (SAA1853) (abinScience Cat# HA089013, RRID:AB_3727616)
_x005F_x000D_

형태

Liquid

저장 완충액

0.01M PBS pH 7.4.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:2000-1:20000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

배경

R-spondin-2 (RSPO2) is a ~28 kDa protein. Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. During embryonic development, plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form.

1. de Lau, W. et al. (2011) Nature 476, 293-7. PMID: 21727895

2. Glinka, A. et al. (2011) EMBO reports 12, 1055-61. PMID: 21909076

3. Gong, X. et al. (2012) PloS one 7, e37137. PMID: 22615920

4. Szenker-Ravi, E. et al. (2018) Nature 557, 564-569. PMID: 29769720

참고사항

For research use only.

이미지

SDS-PAGE

SDS-PAGE for Anti-Human RSPO2 Antibody (SAA1853)

참고 문헌

데이터시트

Anti-Human R-Spondin 2 Recombinant Antibody (SAA1853).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human R-Spondin 2 Recombinant Antibody (SAA1853) (HA089013)

개요

이미지

참고 문헌

데이터시트

SDS

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