中文
English
한국어
日本語
Español
Français
Русский
| 카탈로그 번호 | HF959013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | ELISA | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a, kappa | ||||
| 클론 ID | SAA1523 | ||||
| 타겟 | SCN2B, Sodium channel subunit beta-2 | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | O60939 | ||||
| RRID | Anti-Human SCN2B Antibody (SAA1523) (abinScience Cat# HF959013, RRID:AB_3727284) |
||||
| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
||||
| 제품 사용 정보 |
| ||||
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Sodium channel regulatory subunit beta-2 (SCN2B) is a ~24 kDa protein. Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels. 1. Watanabe, H. et al. (2009) Circulation. Arrhythmia and electrophysiology 2, 268-75. PMID: 19808477 2. Riuró, H. et al. (2013) Human mutation 34, 961-6. PMID: 23559163 3. Das, S. et al. (2016) eLife 5. PMID: 26894959 4. Pan, X. et al. (2019) Science (New York, N.Y.) 363, 1309-1313. PMID: 30765605 5. Shen, H. et al. (2019) Science (New York, N.Y.) 363, 1303-1308. PMID: 30765606 6. Li, X. et al. (2022) Nature communications 13, 1286. PMID: 35277491 7. Li, Y. et al. (2023) Nature communications 14, 1030. PMID: 36823201 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human SCN2B Antibody (SAA1523)
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
