Anti-Human SCN2B Polyclonal Antibody (HF959014)

Name: Anti-Human SCN2B Polyclonal Antibody
Brand: abinScience
SKU: HF959014
Price: 168 USD
Availability: InStock

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개요
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개요

카탈로그 번호

HF959014

설명

Anti-Human SCN2B Polyclonal Antibody (HF959014) is a rabbit polyclonal antibody detecting SCN2B in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human SCN2B (Met30-Ala159).

타겟

Sodium channel subunit beta-2, SCN2B, UNQ326/PRO386

정제

Purified by antigen affinity column.

등록번호

O60939

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Sodium channel regulatory subunit beta-2 (SCN2B) is a ~24 kDa protein. Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels.

1. Watanabe, H. et al. (2009) Circulation. Arrhythmia and electrophysiology 2, 268-75. PMID: 19808477

2. Riuró, H. et al. (2013) Human mutation 34, 961-6. PMID: 23559163

3. Das, S. et al. (2016) eLife 5. PMID: 26894959

4. Pan, X. et al. (2019) Science (New York, N.Y.) 363, 1309-1313. PMID: 30765605

5. Shen, H. et al. (2019) Science (New York, N.Y.) 363, 1303-1308. PMID: 30765606

6. Li, X. et al. (2022) Nature communications 13, 1286. PMID: 35277491

7. Li, Y. et al. (2023) Nature communications 14, 1030. PMID: 36823201

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-Human SCN2B Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human SCN2B Polyclonal Antibody (HF959014)

개요

이미지

참고 문헌

데이터시트

SDS