中文
English
한국어
日本語
Español
Français
Русский
| 카탈로그 번호 | HC420034 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human TRIM28 Polyclonal Antibody (HC420034) is a rabbit polyclonal antibody detecting TRIM28. Suitable for Mouse, Human, and Rat.
Highlights
|
||||||||
| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human TRIM28 (Ser50-Gln243). | ||||||||
| 타겟 | E3 SUMO-protein ligase TRIM28, EC:2.3.2.27, KAP-1, KAP1, KRAB-associated protein 1, KRAB-interacting protein 1, KRIP-1, Nuclear corepressor KAP-1, RING finger protein 96, RING-type E3 ubiquitin transferase TIF1-beta, RNF96, TIF1-beta, TIF1B, TRIM28, Transcription intermediary factor 1-beta, Tripartite motif-containing protein 28 | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 순도 | >95% as determined by SDS-PAGE. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q13263 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
||||||||
| 제품 사용 정보 |
| ||||||||
| 배경 | Transcription intermediary factor 1-beta (TRIM28) is a ~88 kDa protein. Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. 1. Huang, C. et al. (2013) Journal of immunology (Baltimore, Md. : 1950) 190, 4470-3. PMID: 23543754 2. Serra, RW. et al. (2014) eLife 3, e02313. PMID: 24623306 3. Valle-García, D. et al. (2016) Epigenetics 11, 398-414. PMID: 27029610 | ||||||||
| 참고사항 | For research use only |
문의하기
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
