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| 카탈로그 번호 | MF914013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human, Mouse | ||||
| 응용 분야 | ELISA | ||||
| 숙주 종 | Rat | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG1, kappa | ||||
| 클론 ID | MOR04454 | ||||
| 타겟 | Dickkopf-1, SK, hDkk-1, Dkk-1, Dickkopf-related protein 1, DKK1 | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | O54908 | ||||
| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Dickkopf-related protein 1 (DKK1) is a ~29 kDa protein. Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning. 1. Chen, L. et al. (2008) The Journal of biological chemistry 283, 23364-70. PMID: 18524778 2. Causeret, F. et al. (2016) Cell death and differentiation 23, 323-32. PMID: 26206087 3. Ellwanger, K. et al. (2008) Molecular and cellular biology 28, 4875-82. PMID: 18505822 | ||||
| 참고사항 | For research use only. | ||||
| Isotype Control | Rat IgG1, kappa Recombinant Isotype Control Antibody (RTK2071) (RV080407) |
SDS-PAGE for Anti-Mouse DKK1 Antibody (MOR04454)
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중국 우한시 심둔사로 666번지 C동, 우한, 430206
