Anti-Mouse DKK1 Polyclonal Antibody (MF914014)

Name: Anti-Mouse DKK1 Polyclonal Antibody
Brand: abinScience
SKU: MF914014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

MF914014

Description

Anti-Mouse DKK1 Polyclonal Antibody (MF914014) is a rabbit polyclonal antibody detecting DKK1 in ELISA, IHC, WB. Suitable for Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Mouse DKK1 (Ile184-His272).

Target

Dickkopf-1, SK, hDkk-1, Dkk-1, Dickkopf-related protein 1, DKK1

Purification

Purified by antigen affinity column.

Accession

O54908

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Dickkopf-related protein 1 (DKK1) is a ~29 kDa protein. Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning.

1. Chen, L. et al. (2008) The Journal of biological chemistry 283, 23364-70. PMID: 18524778

2. Causeret, F. et al. (2016) Cell death and differentiation 23, 323-32. PMID: 26206087

3. Ellwanger, K. et al. (2008) Molecular and cellular biology 28, 4875-82. PMID: 18505822

Note

For research use only.

Images

References

Datasheet

Anti-Mouse DKK1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Mouse DKK1 Polyclonal Antibody (MF914014)

Overview

Images

References

Datasheet

SDS

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