Anti-Mouse Beta-NGF Recombinant Antibody (alphaD11) (MF909033)

Name: Anti-Mouse Beta-NGF Recombinant Antibody (alphaD11)
Brand: abinScience
SKU: MF909033
Price: 110 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

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사양:

20ug
50ug
100ug
1mg

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개요
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참고 문헌
데이터시트
SDS

개요

카탈로그 번호

MF909033

설명

Anti-Mouse Beta-NGF Recombinant Antibody (alphaD11) (MF909033) is a mouse monoclonal antibody detecting beta-NGF in ELISA, FCM. Suitable for Mouse, Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Mouse, Rat

응용 분야

ELISA, FCM

숙주 종

Mouse

클론성

Monoclonal

이소타입

IgG2a, kappa

클론 ID

alphaD11

타겟

Beta-NGF, Beta-nerve growth factor, NGF, NGFB

내독소 수준

< 10 EU/mg

순도

>95% as determined by SDS-PAGE.

정제

Protein A/G purified from cell culture supernatant.

등록번호

P01139

RRID

Anti-Mouse NGF/Beta-NGF Antibody (alphaD11) (abinScience Cat# MF909033, RRID:AB_3725669)

형태

Liquid

저장 완충액

0.01M PBS pH 7.4.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:2000-1:20000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Beta-nerve growth factor (NGF/Beta-NGF) is a ~27 kDa protein. Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival. The immature NGF precursor (proNGF) functions as a ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI.

1. Feng, D. et al. (2010) Journal of molecular biology 396, 967-84. PMID: 20036257

2. Tong, Q. et al. (2012) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 26, 3811-21. PMID: 22649032

3. Deinhardt, K. et al. (2011) Science signaling 4, ra82. PMID: 22155786

4. Sun, HL. et al. (2015) Acta crystallographica. Section F, Structural biology communications 71, 906-12. PMID: 26144237

참고사항

For research use only.

Isotype Control

Mouse IgG2a (Fc Silence) Recombinant Isotype Control (MOPC 173) (MF533023)

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