Anti-NTRK1 Polyclonal Antibody (HY107014)

Name: Anti-NTRK1 Polyclonal Antibody
Brand: abinScience
SKU: HY107014
Price: 168 USD
Availability: InStock

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개요
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개요

카탈로그 번호

HY107014

설명

Anti-NTRK1 Polyclonal Antibody (HY107014) is a rabbit polyclonal antibody detecting NTRK1 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant human NTRK1 (Asp38-Phe378).

타겟

High affinity nerve growth factor receptor, EC:2.7.10.1, Neurotrophic tyrosine kinase receptor type 1, TRK1-transforming tyrosine kinase protein, Tropomyosin-related kinase A, Tyrosine kinase receptor, Tyrosine kinase receptor A, Trk-A, gp140trk, p140-TrkA, NTRK1, MTC, TRK, TRKA

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

P04629

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

High affinity nerve growth factor receptor (NTRK1) is a ~87 kDa protein. Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand. Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation.

1. Jing, S. et al. (1992) Neuron 9, 1067-79. PMID: 1281417

2. Tacconelli, A. et al. (2004) Cancer cell 6, 347-60. PMID: 15488758

3. Wehrman, T. et al. (2007) Neuron 53, 25-38. PMID: 17196528

4. Klein, R. et al. (1991) Cell 65, 189-97. PMID: 1849459

5. Hempstead, BL. et al. (1991) Nature 350, 678-83. PMID: 1850821

6. Tong, Q. et al. (2012) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 26, 3811-21. PMID: 22649032

7. Anta, B. et al. (2016) The Journal of biological chemistry 291, 19132-45. PMID: 27445338

8. Barker, PA. et al. (1993) The Journal of biological chemistry 268, 15150-7. PMID: 8325889

참고사항

For research use only

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