

| 카탈로그 번호 | HF729011 |
|---|---|
| 설명 |
Recombinant Human MPIG6B/G6b Protein, C-His (HF729011) expressed in Mammalian Cells, spanning Met1-Gln142. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | Mammalian cells |
| 등록번호 | O95866 |
| 단백질 길이 | Met1-Gln142 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 16.25 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | C6orf25, G6B, G6B-B, MPIG6B, Megakaryocyte and platelet inhibitory receptor G6b, Protein G6b |
| 배경 | Megakaryocyte and platelet inhibitory receptor G6b is a ~26 kDa protein. Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production. Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6:FcRgamma signaling. Appears to operate in a calcium-independent manner. 1. Gevaert, K. et al. (2003) Nature biotechnology 21, 566-9. PMID: 12665801 2. Newland, SA. et al. (2007) Blood 109, 4806-9. PMID: 17311996 3. Melhem, M. et al. (2017) European journal of haematology 98, 218-227. PMID: 27743390 |
| 참고사항 | For research use only |
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