Human MPIG6B/G6b Recombinant Protein (C-Fc) (HF729021)

Name: Human MPIG6B/G6b Recombinant Protein (C-Fc)
Brand: abinScience
SKU: HF729021
Price: 298 USD
Availability: InStock

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Overview

Catalog No.	HF729021
Description	Recombinant Human MPIG6B/G6b Protein, C-Fc (HF729021) expressed in Mammalian Cells, spanning Met1-Gln142. Purity: >90% by SDS-PAGE. Highlights ●Fc Fusion — Enhanced stability with Protein A/G purification compatibility. ●Mammalian Expression — Proper folding and native glycosylation. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	Mammalian cells
Accession	O95866
Protein length	Met1-Gln142
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	41.69 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	C6orf25, G6B, G6B-B, MPIG6B, Megakaryocyte and platelet inhibitory receptor G6b, Protein G6b
Background	Megakaryocyte and platelet inhibitory receptor G6b is a ~26 kDa protein. Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production. Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6:FcRgamma signaling. Appears to operate in a calcium-independent manner. 1. Gevaert, K. et al. (2003) Nature biotechnology 21, 566-9. PMID: 12665801 2. Newland, SA. et al. (2007) Blood 109, 4806-9. PMID: 17311996 3. Melhem, M. et al. (2017) European journal of haematology 98, 218-227. PMID: 27743390
Note	For research use only

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Datasheet

Human MPIG6B/G6b Recombinant Protein (C-Fc).pdf

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Human MPIG6B/G6b Recombinant Protein (C-Fc) (HF729021)

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