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| 카탈로그 번호 | HV475086 |
|---|---|
| 설명 |
Anti-Human GITR/TNFRSF18 Reference Antibody (JNJ-64164711, RUO) (HV475086) is a human monoclonal antibody detecting GITR/TNFRSF18. Expressed in Mammalian cells.
|
| 종 반응성 | Human |
| 응용 분야 | ELISA, Bioactivity: FCM, Functional assay, Research in vivo |
| 숙주 종 | Human |
| 클론성 | Monoclonal |
| 이소타입 | IgG |
| 클론 ID | JNJ-64164711 |
| 생물학적 활성 | JNJ-64164711 binds human GITR with high affinity (K d = 180 pM), interacts with human FcγRIIIa variants, targets the CRD1 domain of GITR, and does not inhibit GITR-GITRL binding [1]. JNJ-64164711 mediates greater ADCC-driven depletion of GITR + HuT102, KMS-12-BM, RPMI 8226, JJN-3 cell lines, primary activated GITR + T cells, and in vitro expanded Tregs than other clinical-stage GITR agonist monoclonal antibodies [1]. JNJ-64164711 selectively depletes intratumoral effector Tregs in dissociated primary human patient tumor samples [1]. |
| 발현 시스템 | Mammalian cells |
| 성질 | Recombinant |
| 타겟 | Activation-inducible TNFR family receptor, GITR, TNFRSF18, CD357, Tumor necrosis factor receptor superfamily member 18, AITR, Glucocorticoid-induced TNFR-related protein |
| 내독소 수준 | < 10 EU/mg as determined by LAL method. |
| 순도 | >95% as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | Q9Y5U5 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | JNJ-64164711, JNJ64164711, JNJ64164711 |
| 배경 | Tumor necrosis factor receptor superfamily member 18 (CD357/GITR) is a ~26 kDa protein. Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway. |
| 참고 문헌 | 1. Holland C V, et al. Development of JNJ-64164711, a low fucose anti-GITR antibody for enhanced depletion of tumor regulatory T cells (Tregs)[J]. Cancer Research, 2018, 78(13_Supplement): 3813-3813. [HV475086] |
| 참고사항 | For research use only. Not suitable for clinical or therapeutic use. |
| Isotype Control | Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507) |
SDS-PAGE for Research Grade Anti-Human CD357/TNFRSF18/GITR (JNJ-64164711)
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