Anti-Human Fibronectin Reference Antibody (HuBC-1-hIL12, RUO) (HY259026)

Name: Anti-Human Fibronectin Reference Antibody (HuBC-1-hIL12, RUO)
Brand: abinScience
SKU: HY259026
Price: 370 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

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사양:

100ug
1mg
5mg
10mg
25mg
50mg
100mg

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개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호

HY259026

종 반응성

Human

응용 분야

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

숙주 종

Human

클론성

Monoclonal

이소타입

IgG1-hIL12, kappa

클론 ID

HuBC-1-hIL12

생물학적 활성

Fibronectin (FN) is a glycoprotein present in blood as well as in cells. While Fibronectin (FN) in blood has many functions, its primary role is to promote wound repair following injury [1]. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans (e.g. syndecans) [2].

발현 시스템

Mammalian cells

타겟

EDB, Cold-insoluble globulin, CIG, FN, Fibronectin, FN1

내독소 수준

< 10 EU/mg

순도

>95% purity as determined by SDS-PAGE.

정제

Protein A/G purified from cell culture supernatant.

등록번호

P02751

형태

Liquid

저장 완충액

0.01M PBS pH 7.4

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:2000-1:20000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

대체 이름

HuBC-1ScFv, AS1409, hubc1, bc-1, bc1

배경

Fibronectin (FN) is a ~272 kDa protein. Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts. Acts as a ligand for the LILRB4 receptor, inhibiting FCGR1A/CD64-mediated monocyte activation.

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1. Owens, RJ. et al. (1986) The EMBO journal 5, 2825-30. PMID: 3024962

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2. Garcia-Pardo, A. et al. (1987) The Biochemical journal 241, 923-8. PMID: 3593230

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3. Calaycay, J. et al. (1985) The Journal of biological chemistry 260, 12136-41. PMID: 3900070

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4. Rostagno, A. et al. (1994) The Journal of biological chemistry 269, 31938-45. PMID: 7989369

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5. Su, MT. et al. (2021) International immunology 33, 447-458. PMID: 34089617

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참고 문헌

1. Yuan-Wan Sun, et al. Effects of E-Cigarette Aerosols with Varying Levels of Nicotine on Biomarkers of Oxidative Stress and Inflammation in Mice. Chem Res Toxicol. 2021 Apr 19;34(4):1161-1168. [HY259026]
2. Roumen Pankov, et al. Fibronectin at a glance. J Cell Sci. 2002 Oct 15;115(Pt 20):3861-3. [HY259026]

참고사항

For research use only. Not suitable for clinical or therapeutic use.

이미지

참고 문헌

데이터시트

Anti-Human Fibronectin Reference Antibody (HuBC-1-hIL12, RUO).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human Fibronectin Reference Antibody (HuBC-1-hIL12, RUO) (HY259026)

개요

이미지

참고 문헌

데이터시트

SDS

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