Anti-Human Serpin E1/PAI-1 Reference Antibody (MEDI-579, RUO) (HY185016)

Name: Anti-Human Serpin E1/PAI-1 Reference Antibody (MEDI-579, RUO)
Brand: abinScience
SKU: HY185016
Price: 176 USD
Availability: InStock

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개요
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참고 문헌
데이터시트
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개요

카탈로그 번호	HY185016
종 반응성	Human
응용 분야	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
숙주 종	Human
클론성	Monoclonal
이소타입	IgG1-kappa
클론 ID	MEDI-579
발현 시스템	Mammalian cells
타겟	PLANH1, Endothelial plasminogen activator inhibitor, SERPINE1, Plasminogen activator inhibitor 1, PAI1, PAI, PAI-1, Serpin E1
내독소 수준	< 10 EU/mg
순도	>95% purity as determined by SDS-PAGE.
정제	Protein A/G purified from cell culture supernatant.
등록번호	P05121
형태	Liquid
저장 완충액	0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
대체 이름	MEDI-579, MEDI579, MEDI579
배경	Plasminogen activator inhibitor 1 (SERPINE1/PAI-1) is a ~45 kDa protein. Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. 1. Szabo, R. et al. (2005) The Biochemical journal 390, 231-42. PMID: 15853774 2. Jankun, J. et al. (2007) International journal of molecular medicine 20, 683-7. PMID: 17912461 3. Lee, MH. et al. (1993) Blood 81, 2357-62. PMID: 8481516 4. Fay, WP. et al. (1997) Blood 90, 204-8. PMID: 9207454 5. Anisuzzaman et al. (2011) Biochemical and biophysical research communications 413, 599-604. PMID: 21925150 6. Planus, E. et al. (1997) Journal of cell science 110 ( Pt 9), 1091-8. PMID: 9175705 7. Degryse, B. et al. (2004) The Journal of biological chemistry 279, 22595-604. PMID: 15001579 8. Kjøller, L. et al. (1997) Experimental cell research 232, 420-9. PMID: 9168821 9. Providence, KM. et al. (2008) Archives of dermatological research 300, 303-10. PMID: 18386027 10. Kortlever, RM. et al. (2006) Nature cell biology 8, 877-84. PMID: 16862142
참고 문헌	1. Tang Z, et al. Surface immobilization of a protease through an inhibitor-derived affinity ligand: a bioactive surface with defensive properties against an inhibitor. Chem Commun (Camb). 2015 Sep 28;51(75):14263-6. [HY185016]
참고사항	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 (LALAPG) Recombinant Isotype Control Antibody (HyHEL-10) (HP688307)