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| 카탈로그 번호 | HC424026 |
|---|---|
| 설명 |
laventatug (HC424026) is a research-grade recombinant antibody targeting SLC39A6.
Highlights
|
| 종 반응성 | Human |
| 응용 분야 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 숙주 종 | Human |
| 클론성 | Monoclonal |
| 이소타입 | IgG1, Kappa |
| 종 | Human |
| 타겟 | SLC39A6 |
| 내독소 수준 | < 10 EU/mg |
| 순도 | >95% as determined by SDS-PAGE. |
| 등록번호 | Q13433 |
| 형태 | Liquid |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | 3009829-91-5 |
| 배경 | Zinc transporter ZIP6 (SLC39A6) is a ~85 kDa protein. Zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT). When associated with SLC39A10, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial- to-mesenchymal transition (EMT). The SLC39A10-SLC39A6 heterodimer also controls NCAM1 phosphorylation and its integration into focal adhesion complexes during EMT. Zinc influx inactivates GSK3B, enabling unphosphorylated SNAI1 in the nucleus to down-regulate adherence genes such as CDH1, causing loss of cell adherence. In addition, the SLC39A10-SLC39A6 heterodimer plays an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis. 1. Taylor, KM. et al. (2003) The Biochemical journal 375, 51-9. PMID: 12839489 2. Chowanadisai, W. et al. (2008) Brain research 1199, 10-9. PMID: 18272141 3. Yu, M. et al. (2011) The Journal of experimental medicine 208, 775-85. PMID: 21422171 4. Hogstrand, C. et al. (2013) The Biochemical journal 455, 229-37. PMID: 23919497 5. Taylor, KM. et al. (2016) The Biochemical journal 473, 2531-44. PMID: 27274087 6. Kim, B. et al. (2021) Frontiers in immunology 12, 687367. PMID: 34394081 7. Nimmanon, T. et al. (2021) Cellular and molecular life sciences : CMLS 78, 1781-1798. PMID: 32797246 |
| 참고사항 | For research use only. Not suitable for clinical or therapeutic use. |
SDS-PAGE for Research Grade laventatug
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중국 우한시 심둔사로 666번지 C동, 우한, 430206
