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| 카탈로그 번호 | HY285016 |
|---|---|
| 설명 |
Lesigercept (HY285016) is a research-grade recombinant antibody targeting FcERI. Produced in mammalian cells with native-like glycosylation.
Highlights
|
| 종 반응성 | Human |
| 응용 분야 | ELISA, Functional assay, Research in vivo |
| 이소타입 | Human FcERI (IgE Fc receptor subunit alpha) extracellular domain fragment fused to a Fc fragment of human IgG4 |
| 발현 시스템 | Mammalian cells |
| 타겟 | FcERI, IgE Fc receptor subunit alpha, FCER1A, Fc-epsilon RI-alpha, FCE1A, High affinity immunoglobulin epsilon receptor subunit alpha |
| 내독소 수준 | < 10 EU/mg |
| 순도 | >95% purity as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | P12319 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | 2878448-12-3 |
| 배경 | High affinity immunoglobulin epsilon receptor subunit alpha (FCER1A/FcERI) is a ~29 kDa protein. High-affinity receptor for immunoglobulin epsilon/IgE. Mediates IgE effector functions in myeloid cells. Upon IgE binding and antigen/allergen cross-linking initiates signaling pathways that lead to myeloid cell activation and differentiation. On mast cells, basophils and eosinophils stimulates the secretion of vasoactive amines, lipid mediators and cytokines that contribute to inflammatory response, tissue remodeling and cytotoxicity against microbes. Triggers the immediate hypersensitivity response to allergens as a host defense mechanism against helminth parasites, pathogenic bacteria and venom toxicity. |
| 참고사항 | For research use only. Not suitable for clinical or therapeutic use. |
SDS-PAGE for Research Grade Lesigercept
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