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| 카탈로그 번호 | HC295016 |
|---|---|
| 설명 |
rapaprutug (HC295016) is a research-grade recombinant antibody targeting KARS1/Lysyl-tRNA synthetase.
Highlights
|
| 종 반응성 | Human |
| 응용 분야 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 숙주 종 | Human |
| 클론성 | Monoclonal |
| 이소타입 | IgG1, Kappa |
| 종 | Human |
| 타겟 | KARS1/Lysyl-tRNA synthetase |
| 내독소 수준 | < 10 EU/mg |
| 순도 | >95% as determined by SDS-PAGE. |
| 등록번호 | Q15046 |
| 형태 | Liquid |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | 2994192-38-8 |
| 배경 | Lysine--tRNA ligase (KARS1/Lysyl-tRNA synthetase) is a ~68 kDa protein. Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity. 1. Guzzo, CM. et al. (2008) Biochemical and biophysical research communications 365, 718-23. PMID: 18029264 2. Guo, M. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 2331-6. PMID: 18272479 3. Shiba, K. et al. (1997) The Journal of biological chemistry 272, 22809-16. PMID: 9278442 4. Park, SG. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 6356-61. PMID: 15851690 5. Lee, YN. et al. (2004) Immunity 20, 145-51. PMID: 14975237 6. Yannay-Cohen, N. et al. (2009) Molecular cell 34, 603-11. PMID: 19524539 7. Ofir-Birin, Y. et al. (2013) Molecular cell 49, 30-42. PMID: 23159739 8. Zamecnik, PC. et al. (1966) Biochemical and biophysical research communications 24, 91-7. PMID: 5338216 |
| 참고사항 | For research use only. Not suitable for clinical or therapeutic use. |
SDS-PAGE for Research Grade rapaprutug
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
