Anti-Human GDF-15 Reference Antibody (Visugromab, RUO) (HV986026)

Name: Anti-Human GDF-15 Reference Antibody (Visugromab, RUO)
Brand: abinScience
SKU: HV986026
Price: 176 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

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100ug
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개요
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참고 문헌
데이터시트
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개요

카탈로그 번호	HV986026
설명	Visugromab (HV986026) is a research-grade recombinant antibody targeting PLAB. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
종 반응성	Human
응용 분야	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
숙주 종	Human
클론성	Monoclonal
이소타입	IgG4-kappa
발현 시스템	Mammalian cells
타겟	PLAB, Placental bone morphogenetic protein, MIC1, NRG-1, PTGFB, NSAID-regulated gene 1 protein, GDF15, NAG-1, MIC-1, Prostate differentiation factor, NSAID-activated gene 1 protein, Growth/differentiation factor 15, Macrophage inhibitory cytokine 1, Placental TGF-beta, GDF-15, PDF
내독소 수준	< 10 EU/mg
순도	>95% purity as determined by SDS-PAGE.
정제	Protein A/G purified from cell culture supernatant.
등록번호	Q99988
형태	Liquid
저장 완충액	0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
대체 이름	CTL002, CTL-002, CTL002, 2556646-63-8
배경	Growth/differentiation factor 15 (GDF15/MIC1) is a ~34 kDa protein. Hormone produced in response to various stresses to confer information about those stresses to the brain, and trigger an aversive response, characterized by nausea, vomiting, and/or loss of appetite. The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future. Acts by binding to its receptor, GFRAL, activating GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem. It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes responses to stressful conditions. The GDF15-GFRAL signal induces expression of genes involved in metabolism, such as lipid metabolism in adipose tissues. 1. Tsai, VW. et al. (2013) PloS one 8, e55174. PMID: 23468844 2. Tsai, VW. et al. (2014) PloS one 9, e100370. PMID: 24971956 3. Mullican, SE. et al. (2017) Nature medicine 23, 1150-1157. PMID: 28846097 4. Emmerson, PJ. et al. (2017) Nature medicine 23, 1215-1219. PMID: 28846098 5. Yang, L. et al. (2017) Nature medicine 23, 1158-1166. PMID: 28846099 6. Hsu, JY. et al. (2017) Nature 550, 255-259. PMID: 28953886 7. Xiong, Y. et al. (2017) Science translational medicine 9. PMID: 29046435 8. Patel, S. et al. (2019) Cell metabolism 29, 707-718.e8. PMID: 30639358 9. Coll, AP. et al. (2020) Nature 578, 444-448. PMID: 31875646 10. Klein, AB. et al. (2021) Nature communications 12, 1041. PMID: 33589633
참고사항	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG4 (S228P) Recombinant Isotype Control Antibody (13R4) (HP298207)